Ok going to do a series of post on different levels that have sections that when you lose you feel a bit robbed. I feel the end section of A Low Blow is one.
At higher difficulties or against a semi skilled antagonist (general playing as Konstantin) taking down the last shield is very difficult without choosing characters and weapons specifically for that section.
Between the high spawn rate of the dreaded shotgun men and Konstantin spawning directly behind you dropping repulsion spheres it feels a tad like shooting fish in a barrel, as there isn't really anywhere to take cover.
It's not impossible, it just doesn't feel quite right it terms of the flow of the level up until that point.
If you are going to lose against an antagonist it is most likely on this section, 2 minutes before the end, seemingly regardless of performance before then.